Our Products
Mastering the three key anti-aging moisturizing elements, the first patented Biotechnology DNA medical technology combines 2000IU active unit gene recombinant EGF and bFGF growth factor anti-wrinkle formula, and adds natural HA hyaluronic acid moisturizing factor to continuously hydrate the skin and establish a strong It locks in moisture barrier and penetrates deep into the skin to strengthen cell proliferation, prevent collagen breakage, resist aging cells, quickly repair wrinkles and scars, awaken the regeneration function of young cells, and comprehensively rebuild youthful and radiant skin.
What is EGF?
EGF (Epidermal Growth Factor), whose scientific name is “epidermal growth factor”, is an important cell growth factor secreted in the human body and has strong physiological activity. Its main function is to promote the division of skin cells.
In 1962, American scientist Dr. Cohen discovered the “epidermal growth factor” EGF, which determines skin age, and further confirmed that the lack of EGF is the fundamental cause of skin aging. This great discovery made Dr. Cohen the winner of the Nobel Prize in Medicine and Physiology in 1986. His research theory shows that supplementing EGF to the skin can restore youthfulness and firmness to aging skin. A very small amount of EGF can promote and stimulate cell growth, effectively inhibit aging genes, delay skin aging, and maintain the optimal physiological state of each component of the skin. . In addition, EGF can also stimulate the synthesis and secretion of some extracellular macromolecules (such as hyaluronic acid and collagen) to moisturize the skin, which is a key factor in determining skin vitality and health. Since then, the mystery of skin youthfulness and aging has been revealed, and the dream of human beings regaining their youth has become a reality.
What is bFGF?
bFGF (basic fibroblast growth factor), also known as “basic fibroblast growth factor”, is a multi-potent cell growth factor that widely acts on tissues and cells derived from mesoderm and neuroectoderm. It can promote the division and proliferation of fibroblasts in the dermis of the skin, repair aging and damaged dermal tissue, restore the elastic fiber structure of the skin, improve skin sagging, wrinkles, scars, dullness and other problems in a short period of time, and restore skin elasticity. Another important function of bFGF is to promote angiogenesis, which can chemoattract various cells in the lining of blood vessels and stimulate their proliferation and migration, thereby causing skin tissue to rapidly generate new blood vessels, enriching the subcutaneous blood microcirculation system, and nourishing skin tissue. bFGF is also a neurotrophic factor that promotes growth, differentiation and survival of subcutaneous nerve tissue, improves the skin’s ability to perceive harmful external intrusions, and enhances the skin’s resistance.
*Supplement: Fibroblast Growth factor (FGF) was originally extracted and purified from the bovine pituitary gland. It was named after it can promote the proliferation of fibroblast cell line NIH3T3cells.
In the decades since aFGF (FGF-1) was purified in 1970, different FGFs have been discovered, namely: FGF-1 (aFGF), FGF-2 (bFGF), FGF-3 (INT-2) , FGF-4(HST-1), FGF-5, FGF-6 (HST-2), FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GGF), FGF-10, FGF- 11 (FHF-3), FGF-12 (FHF-1), FGF-13 (FHF-2), FGF-14 (FHF-4) and FGF-15, etc., these are called fibroblast growth The factor family (FGF family) has in common that it has a heparin binding domain in its structure, so it is also called heparin binding growth factor (HBGF)
Studies have pointed out that FGFs have functions such as regulating cell growth, survival, differentiation and migration (Rider et al., 1995). Moreover, basal fibroblast growth factor stimulates the growth of many types of cells and has the ability to stimulate the proliferation of new blood vessels. It can also stimulate the natural synthesis of collagen and elastin, enhance skin elasticity and reduce wrinkles. In addition, basal fibroblast growth factor is also an important growth factor in the wound healing process. Its main functions are as follows: skin regeneration, stimulating collagen and elastin synthesis, stimulating fibroblast growth, stimulating aging tissue regeneration and wound healing, stimulating epidermal cell growth and movement, stimulating hair growth, preventing the formation of white hair and stimulating hyaluronic acid synthesis. According to previous studies, bFGF has the effect of promoting the growth of vascular smooth muscle cells cultured in vitro, promoting angiogenesis, blood circulation and collagen regeneration, and promoting the cells’ natural wound recovery mechanism.
Early application and production difficulties of EGF and bFGF
EGF and bFGF are both important cell growth factors in the human body. They can effectively promote cell growth and stimulate the body’s repair function. Therefore, they were early used in the treatment of dermatitis, burns, scalds, skin trauma, postoperative wounds, corneal damage, oral ulcers, gastric ulcers, etc. Ulcers, bedsores, gangrene, etc., in the medical field related to wound repair and wound healing. In 1992, James Drug Laboratories in the United States tried to add EGF to cosmetics. EGF can promote the growth and division of various cells in epidermal tissue, make epidermal cells plump, and stimulate the growth of collagen. It can shrink pores, It has a very significant effect in anti-wrinkle and anti-aging, so it was highly sought after by beauty lovers at that time and was known as the “beauty factor”. However, to this day, EGF and bFGF are not widely used in beauty products, which involves two major production problems:
- Difficulty in extraction: EGF and bFGF are natural epidermal growth factors, but these natural factors are difficult to produce on a large scale. Early EGF and bFGF were mainly extracted from placenta and body fluids. However, due to the extremely low content, only 1 gram of EGF or bFGF can be extracted from 10,000 placentas, resulting in a sales price of US$2 million per gram for the growth factor. Sky-high legend.
2. Requires extremely high preservation technology: EGF and bFGF are biologically active proteins. If they lose their activity, they will not be able to play their intended role. Due to the immature storage process in the early stage, the active storage period of growth factors was only a short 7-10 days, which greatly increased the difficulty of application in beauty products.
Focus on scientific research and overcome difficulties
The growth factors used in our products are genetically recombined rhEGF and rhbFGF. rh means structural modification, which is currently the most cutting-edge and breakthrough biotechnology technology in the medical field. We use secreted expression E. coli genetic engineering to culture and obtain high-purity rhEGF and rhbFGF that are homologous to humans and have the same genes. Through fermentation, purification, vacuum freeze-drying and other bioengineering technologies, skin care products containing rhEGF and rhbFGF are produced without adding chemical ingredients, retaining the original activity while meeting the public’s requirements for quality and purity. . In line with the attitude of “keep improving, pragmatic and innovative”, combined with a strict quality control system, we are committed to producing high-quality, highly active and high-purity rhEGF and rhbFGF, and continue to develop the new field of biological beauty for anti-wrinkle and anti-aging. We look forward to witnessing the biological beauty The era of genetic beauty is coming.
Introduction to the efficacy of rhEGF and rhbFGF
Our skin care products add high-purity rhEGF and rhbFGF ingredients and have the following five major skin care effects:
1. Efficient repair
1. EGF and bFGF can promote the proliferation and differentiation of epidermal cells, so that aging and dead cells can be replenished in time, so that damaged epidermis can be repaired immediately. They can be used to adjust various bad skin qualities such as skin resurfacing, redness, telangiectasia, etc., and improve skin. Removes thin, rough, scarred and other undesirable conditions and restores smoothness to the skin. Each growth factor actively binds to specific receptors on the cell membrane near the wound, thereby initiating proteases, accelerating protein synthesis, promoting the growth of fibroblasts, promoting skin and mucosal wound healing, and supporting scar shrinkage and skin deformity hyperplasia, rapidly Efficiently repair wounds. It can be used to treat various injuries to skin tissue, remove acne, acne, small defects after mole removal, peeling and redness after skin resurfacing, skin burns caused by the use of fruit acids, etc., and repair epidermal damage after grinding. effect.
2. Eliminate wrinkles
EGF and bFGF have functions such as promoting the metabolism, proliferation and growth of fibroblasts and epidermal cells, and promoting the development of elastic fiber cells. They help initiate the regeneration of aging cells, accelerate cell metabolism and renewal, rapidly metabolize aging cutin, and repair broken superficial skin cells. Epidermal fibroblasts, thereby eliminating wrinkles. Promote the proliferation of fibroblasts in the dermis through EGF and bFGF active factors, repair aging collagen fibers and elastic fibers; synthesize and secrete more collagen, hyaluronic acid and other macromolecules; improve skin microcirculation and provide good nutrition environment, maintain a certain amount of skin fat, restore skin elasticity, make it even and firm, and reduce wrinkles.
3. Anti-aging
EGF and bFGF can promote the growth and division of epithelial cells, keratinocytes, fibroblasts and other cells in epidermal tissues, accelerate metabolism (anti-aging), and enhance the activity of epidermal cells, thereby maintaining the quality and quantity of cells and making the skin Wrinkles disappear, revealing healthy beauty that is firm, soft, smooth and elastic. EGF and bFGF can reverse differentiation of mature cells to form “stem cell islands”, while inhibiting aging genes, fundamentally changing the composition of skin cells, reducing the average age of skin cells, and making the skin smooth and beautiful.
4. Lighten spots
For darker skin tones and various skin pigmentation problems, EGF and bFGF can accelerate the decomposition and discharge of melanin by promoting blood circulation and cell proliferation, thereby reducing the content of melanin and colored cells in skin cells, and whitening and lightening spots. EGF and bFGF can increase skin blood flow, improve skin microcirculation, provide a good nutritional environment for epidermal cells, prevent the accumulation of metabolic products, effectively improve skin color, reduce pigmentation, and make skin fair, perfect, even and beautiful.
5. Moisturizing
EGF and bFGF can improve skin microcirculation (smoothness), smooth Qi and blood, prevent accumulation of metabolites, and make skin nutritious. In addition, EGF and bFGF can also promote the synthesis and secretion (moisturizing) of hyaluronic acid, promote the synthesis and secretion of extracellular hyaluronic acid, glycoproteins and other macromolecules, enhance the hydrophilicity of the skin, and maintain moisture in the dermis. When the moisture retention capacity of the stratum corneum within the epidermis is enhanced, the skin can be restored to health and be permanently moisturized and radiated vitality.
In addition to EGF and bFGF, the product also adds hyaluronic acid with extremely high moisturizing power to make the skin care formula more perfect.
Hyaluronic acid is the main component of connective tissues such as human interstitium, eye vitreous, and joint synovial fluid. It plays important physiological functions in the body by retaining water, maintaining extracellular space, regulating osmotic pressure, lubrication, and promoting cell repair. Hyaluronic acid molecules contain a large number of carboxyl and hydroxyl groups, which form intramolecular and intermolecular hydrogen bonds in aqueous solution, which makes it have a strong water retention effect and can bind more than 400 times of its own water; at higher concentrations, due to its molecular The complex three-level network structure formed by the interaction between them, and its aqueous solution has significant viscoelasticity. As the main component of the intercellular matrix, hyaluronic acid is directly involved in the regulation of electrolyte exchanges inside and outside cells, and plays a role in the screening program of physical and molecular information. Large molecule hyaluronic acid has an inhibitory effect on cell movement, proliferation, differentiation and phagocytosis, while small molecule hyaluronic acid has a promoting effect. As a result, a dual moisturizing and moisture-locking effect of large molecules locking in moisture and small molecules penetrating and moisturizing is formed, which makes the quality of skin care products extremely sublimated.
The outstanding efficacy of our products relies on advanced rhEGF and rhbFGF extraction technology and the three key formulas of EGF + bFGF + HA. In addition to focusing on efficacy, safety is also one of the indicators of our products. EGF and bFGF are extremely safe skin care ingredients because they are biological factors that can be produced by the human body itself and are composed of 53 amino acids. When we are young, the human body can produce enough EGF and bFGF to promote the growth of epidermal cells. However, as we age, the production of EGF and bFGF gradually decreases, so the renewal rate of epidermal cells becomes slower and slower. Because EGF and bFGF are components of the human body, they have no side effects and are very safe. Compared with other anti-aging and anti-wrinkle methods, safety is definitely the biggest consideration and advantage when choosing our EGF and bFGF skin care products.
護膚、修復作用
bFGF能夠改善細胞生長的微環境，促進彈性纖維和膠原蛋白的合成，使肌膚富有彈性，使皮膚處於滑嫩的狀態。
抗皺、防衰老作用
能夠促進成纖維細胞的生長發育，不斷以新的細胞取代老化細胞，因此產生防皺、祛皺作用。
美白、祛斑作用
更新衰老細胞，從而降低皮膚細胞中黑色素和有色細胞的含量，減輕皮膚色素的沉著。
防曬及曬後修復作用
能迅速修復受損細胞，減輕紫外線輻射對皮膚造成的傷害。
防粉刺、去疤痕作用
刺激皮膚肉芽組織的形成和促進肉芽組織的上皮化，還可調節膠原降解及更新，從而縮短創傷癒合時間以及減少疤痕形成的作用。
能激增神經細胞再生，並促進表皮細胞的新陳代謝，修復表皮，增加肌膚彈性，延緩衰它；並可通過促進新生細胞生成來替代原來的細胞，以降低肌膚中色素細胞的含量，令膚色均勻，光滑白皙，緊緻潤澤。
並促進創傷癒合與組織修復，同時增生多元化潛能幹細胞，最終有助神經元皮質生長。另一方面，能夠促進真皮層鹼性成纖維母細胞和鹼性成纖維細胞分裂，從而促進膠原蛋白和彈力蛋白的形成，增強皮膚的彈性，能促進神經細胞分裂增生繁殖，使肌膚充滿活力，還能促進毛細血管的形成和分化。