Recombinant basic fibroblast growth factor (bFGF) is a very trace active substance in mammals and humans. It is effective on mesoderm and neuroectodermal cells (such as epithelial cells, dermal cells, fibroblasts, and vascular endothelial cells). , bone cells, cartilage cells, neurons and glial cells, etc.) can promote repair and regeneration. Therefore, bFGF has a wide range of physiological functions and important clinical application value.

1) bFGF gene recombination technology

It is extremely difficult to biochemically extract bFGF. Approximately 1 gram of bFGF can be extracted from 10,000 placentas. We have successfully applied genetic recombination technology to modify and recombine the human bFGF gene, and obtained rh-bFGF high-efficiency expression plasmid and production engineering strain, laying the foundation for the industrial production of bFGF.

2) bFGF large-scale production process and quality control technology

We have researched and mastered a series of rh-bFGF large-scale production process technologies such as high-density fermentation of rh-bFGF engineering bacteria and protein separation and purification, and established a complete rh-bFGF stock solution quality control system.